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Search Results for " phenylalanine hydroxylase "

Targets Recommended: Hydroxylase

8

抑制剂 & 化合物

3

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10142L	p-Ethynylphenylalanine hydrochloride 4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base)	Hydroxylase	Metabolism
	p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) 是一种高效的、可逆的、选择性的、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其Ki=32.6 μM。
T1447	Fenclonine Fenchlonine,PCPA,CP-10188,芬克洛宁,4-Chloro-DL-phenylalanine,DL-4-Chlorophenylalanine	Hydroxylase	Metabolism
	Fenclonine (CP-10188) 是一种有效的色氨酸羟化酶(Trp)的不可逆抑制剂。其中色氨酸羟化酶是 5-羟色胺生物合成的限速酶。
T41143	pCPA methyl ester hydrochloride 4-氯-DL-苯基丙氨酸甲酯盐酸盐,4-Chloro-DL-phenylalanine methyl ester hydrochloride	5-HT Receptor; Hydroxylase	GPCR/G Protein; Metabolism; Neuroscience
	pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是色氨酸羟化酶抑制剂和5-HT 合成的抑制剂。 pCPA methyl ester hydrochloride 可穿过血脑屏障并降低 5-HT 中枢可用性。
T10142	p-Ethynylphenylalanine 4-Ethynyl-L-phenylalanine	Others; Hydroxylase	Metabolism; Others
	p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种色氨酸羟化酶(TPH)抑制剂，具有竞争性、有效性、选择性和可逆性，Ki 为32.6 μM。
T41274	p-Fluoro-L-phenylalanine	Hydroxylase	Metabolism
	p-Fluoro-L-phenylalanine 是酪氨酸羟化酶的一种底物。它可以与大肠杆菌的 L-亮氨酸特异性受体结合，KD 为0.26 μM。
T78228	4-Chloro-L-phenylalanine L-4-Chlorophenylalanine,L-PCPA	5-HT Receptor	GPCR/G Protein; Neuroscience
	4-Chloro-L-phenylalanine (L-PCPA) 是一种 5-HT 生物合成抑制剂。4-Chloro-L-phenylalanine 也是色氨酸羟化酶(TPH1 和 TPH2)的非特异性拮抗剂。
T21366	Sapropterin free base BPH4,Dapropterin,6R-BH4,Tetrahydro-6-biopterin,THB,Phenoptin
	Sapropterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of dopamine, epinephrine, melatonin, norepinephrine, neurotransmitter
T36384	DL-Tyrosine-13C9,15N L-Tyrosine-13C9,15N
	L-Tyrosine-13C9,15N is intended for use as an internal standard for the quantification of L-tyrosine by GC- or LC-MS. L-Tyrosine is a non-essential amino acid.1It is produced by hydroxylation of phenylalanine by phenylalanine hydroxylase but can also be obtained from dietary sources or degradation of endogenous proteins, resulting in L-tyrosine release.1,2L-Tyrosine is a precursor in the biosynthesis of catecholamine neurotransmitters, melanins, and thyroid hormones.3Plasma, skeletal muscle, and...

化合物

p-Ethynylphenylalanine hydrochloride

Cat.No: T10142L

Synonym: 4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base)

Target: Hydroxylase

Cat.No: T1447

Synonym: Fenchlonine,PCPA,CP-10188,芬克洛宁,4-Chloro-DL-phenylalanine,DL-4-Chlorophenylalanine

Target: Hydroxylase

pCPA methyl ester hydrochloride

Cat.No: T41143

Synonym: 4-氯-DL-苯基丙氨酸甲酯盐酸盐,4-Chloro-DL-phenylalanine methyl ester hydrochloride

Target: 5-HT Receptor, Hydroxylase

p-Ethynylphenylalanine

Cat.No: T10142

Synonym: 4-Ethynyl-L-phenylalanine

Target: Others, Hydroxylase

p-Fluoro-L-phenylalanine

Cat.No: T41274

Target: Hydroxylase

4-Chloro-L-phenylalanine

Cat.No: T78228

Synonym: L-4-Chlorophenylalanine,L-PCPA

Target: 5-HT Receptor

Sapropterin free base

Cat.No: T21366

Synonym: BPH4,Dapropterin,6R-BH4,Tetrahydro-6-biopterin,THB,Phenoptin

DL-Tyrosine-13C9,15N

Cat.No: T36384

Synonym: L-Tyrosine-13C9,15N

Cat. No.	Product Name	Target	Signaling Pathways
T7117	Sapropterin dihydrochloride Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐,6R-BH4 dihydrochloride,盐酸沙丙蝶呤	Hydroxylase	Metabolism
	Sapropterin dihydrochloride (6R-BH4 dihydrochloride) 是一种合成的 BH4 形式，已经被批准用于 BH4 反应的 PKU 研究。
T4781	N-Acetyl-L-phenylalanine N-Ac-Phenylalanine,N-乙酰-L-苯丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-phenylalanine (N-Ac-Phenylalanine) 是一种大肠杆菌中的主要酰基氨基酸，由 L-苯丙氨酸和乙酰辅酶 A 合成。
T5290	(S)-2-Hydroxy-3-phenylpropanoic acid L-(−)-3-Phenyllactic acid,L-3-苯乳酸	Others; Endogenous Metabolite	Metabolism; Others
	(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) 是苯丙氨酸的代谢产物。苯丙酮尿症患者体液中苯丙氨酸的水平升高。

天然产物

Sapropterin dihydrochloride

Cat.No: T7117

Synonym: Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐,6R-BH4 dihydrochloride,盐酸沙丙蝶呤

Target: Hydroxylase

N-Acetyl-L-phenylalanine

Cat.No: T4781

Synonym: N-Ac-Phenylalanine,N-乙酰-L-苯丙氨酸

Target: Others, Endogenous Metabolite

(S)-2-Hydroxy-3-phenylpropanoic acid

Cat.No: T5290

Synonym: L-(−)-3-Phenyllactic acid,L-3-苯乳酸

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02707	PAH Protein, Human, Recombinant (415 Asn/Asp, His) phenylalanine hydroxylase,PH,PKU1,PKU	Human	Baculovirus Insect Cells
	PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an "inhibitory" domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule. In humans, PAH is expressed both in the liver and the kidney, and there is some indication that it may be differentially reg...
TMPJ-01043	PHS Protein, Human, Recombinant (His) 4-Alpha-Hydroxy-Tetrahydropterin Dehydratase,Pterin-4-α-Carb...	Human	E. coli
	Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type ...

重组蛋白

PAH Protein, Human, Recombinant (415 Asn/Asp, His)

Cat.No: TMPY-02707

Species: Human

Expression System: Baculovirus Insect Cells

PHS Protein, Human, Recombinant (His)

Cat.No: TMPJ-01043

Species: Human

Expression System: E. coli

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